Affinity determination and competition assays using surface plasmon resonance: Equilibrium binding affinities of the interactions between IL-6 and anti-IL-6 antibodies or single chain Fvs
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Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms
Transforming growth factor (TGF)β levels are elevated in, and drive the progression of, numerous disease states such as advanced metastatic cancer and systemic and ocular fibrosis. There are 3 main isoforms, TGFβ1, 2, and 3. As multiple TGFβ isoforms are involved in disease processes, maximal therapeutic efficacy may require neutralization of 2 or more of the TGFβ isoforms. Fully human antibody...
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